PBSE Fall Research Conference

PBSE ANNUAL RESEARCH CONFERENCE

In the fall of each year, PBSE sponsors a research conference at an off-campus location to introduce new predoctoral fellows to our wider research community. Approximately 150 graduate students, postdoctoral fellows, and faculty members from the Departments of Molecular, Cell, and Developmental Biology, Biomolecular Engineering, Chemistry and Biochemistry, and Microbiology and Environmental Toxicology attend. In addition to feature presentations by new PBSE faculty and an invited keynote speaker (see below), the conference  includes numerous short presentations by pre- and postdoctoral fellows. The informal conference format is designed to encourage scientific discussion across disciplines to foster future research collaborations.


 

2017 PBSE Research Conference
Thursday, September 14, 2017

Location: Roaring Camp, 5401 Graham Hill Road, Felton, CA 95018 (directions)

Register Here

Deadline to register is August 14, 2017 

 Joe Pagliano, Professor, UCSDKeynote Speaker: Joe Pogliano, Professor of Molecular Biology, UC San Diego

Dr. Pogliano's Research

Evolution of the microbial cytoskeleton

Prokaryotic cells have a complex subcellular organization but how this organization is established and maintained remains poorly understood due to our limited knowledge of the proteins that make up the prokaryotic cytoskeleton. The goals of my lab are to identify and characterize the major families of dynamic cytoskeletal proteins that exist in bacteria, to determine the various functions that they perform, and to understand how these polymers are regulated spatially and temporally by other factors within the cell. My lab specializes in using genetics and cell biology to study the function and in vivo assembly dynamics of cytoskeletal polymers in many different species of prokaryotes, including E. coli, Bacillus subtillis, B. megaterium, B. thuringiensis, Mycobacterium smegmatis, and Pseudomonas species. Our approach has been to focus on bacterial plasmids as tools to discover new families of cytoskeletal polymers. Plasmids offer the advantages that they are genetically diverse and each encodes its own segregation system. Our studies have led to the discovery of new types of cytoskeletal structures involved in DNA segregation in bacteria (Pogliano 2008), including a new family of tubulins (TubZ) (Larsen et al. 2007) and a new family of actins (AlfA) (Becker et al. 2006). To complete some of our long term goals, we have initiated collaborations with biochemists, structural biologists and physicists to study polymer assembly in vitro and in silico to generate an integrated and detailed mechanistic understanding of cytoskeletal dynamics in prokaryotes. Studies of the bacterial cytoskeleton will lead to an understanding of how prokaryotic cells generate and maintain their subcellular organization and will provide insight into how the eukaryotic cytoskeleton evolved.

See Dr. Pogliano's website for more information about his research.

Program Schedule and Speaker Bios: Click Here


 

NIH
UCSC's graduate Program in Biomedical Sciences and Engineering is supported by training grants from the National Institute of General Medical Science and the National Human Genome Research Institute.